Clinicopathologic and mucin histochemical analyses of 90 cases of ovarian mucinous borderline tumors of intestinal and müllerian types.

Clinicopathologic and mucin histochemical characteristics of 90 cases of ovarian mucinous borderline tumors (MBT) of intestinal (IMBT) and müllerian types (MMBT) were studied to determine whether IMBT and MMBT constitute distinct tumor subtypes. The IMBT (77 cases, 78 lesions) contained goblet cells, absorptive cells and endocrine cells, which represented intestinal differentiation. The average diameter of IMBT was 13.4 cm. Five patients (6.5%) had stage III disease with pseudomyxoma peritonei and one of them died from tumor. Approximately 50% of IMBT demonstrated gastrointestinal characteristics on mucin histochemistry. The MMBT (13 cases, 14 lesions) consisted of mucous columnar cells and eosinophilic cells, with no intestinal differentiation. MMBT accounted for 15.2% of MBT. MMBT averaged 8.4 cm in diameter, and 29% were associated with endometriosis of the Ipsilateral ovary. All patients with MMBT had stage I disease, and none suffered from pseudomyxoma peritonei. All patients whose follow-up data were available were alive and well, without evidence of tumor recurrence. The mucin histochemical findings in MMBT resembled those of normal endocervix. Results of the present study suggest that IMBT and MMBT have different characteristics and constitute distinct subtypes of MBT.
AuthorsK Nomura, S Aizawa
JournalPathology international (Pathol Int) Vol. 46 Issue 8 Pg. 575-80 (Aug 1996) ISSN: 1320-5463 [Print] Australia
PMID8893226 (Publication Type: Journal Article)
Chemical References
  • Mucins
  • Adolescent
  • Adult
  • Aged
  • Cystadenocarcinoma, Mucinous (chemistry, pathology)
  • Female
  • Histocytochemistry
  • Humans
  • Middle Aged
  • Mixed Tumor, Mullerian (chemistry, pathology)
  • Mucins (analysis)
  • Ovarian Neoplasms (chemistry, pathology)
  • Precancerous Conditions (chemistry, pathology)
  • Pseudomyxoma Peritonei (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: