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Transient complete remission of acute lymphoblastic leukemia in relapse after allogeneic bone marrow transplantation induced by donor leukocyte transfusions.

Abstract
We report the case of a young patient with refractory acute lymphoblastic leukemia relapse, after allogeneic bone marrow transplantation, who was treated by donor leukocyte infusions. We observed potent adoptive immunotherapy which produced a cytologic complete remission and total chimeric state. This was of short duration and the patient died of severe graft-versus-host disease. We present a short summary of the literature concerning acute lymphoblastic leukemia and donor leukocyte infusions.
AuthorsL D'Hondt, C Chatelain, C Doyen, J C Osselaer, A Ferrant, A Bosly
JournalHematology and cell therapy (Hematol Cell Ther) Vol. 38 Issue 4 Pg. 353-4 (Aug 1996) ISSN: 1269-3286 [Print] France
PMID8891727 (Publication Type: Case Reports, Journal Article)
Topics
  • Adolescent
  • Bone Marrow Transplantation
  • Humans
  • Leukocyte Transfusion
  • Male
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (pathology, therapy)
  • Recurrence
  • Transplantation, Homologous

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