Synergistic effect of aurintricarboxylic acid and triflavin in a photochemically induced thrombosis model in rats.

Abstract

We report here the synergistic antithrombotic effect of aurintricarboxylic acid in combination with a snake venom-derived disintegrin, triflavin, in a photochemically induced thrombosis model in rats. The time to initiation of thrombus was prolonged by i.v. bolus injection of aurintricarboxylic acid at 10 mg/kg. In contrast, time to occlusion was dose-dependently prolonged by both agents, this prolongation being significant with aurintricarboxylic acid at 10 mg/kg i.v. and with triflavin at more than 3 mg/kg i.v. Interestingly, the combination of aurintricarboxylic acid at 3 mg/kg i.v. and triflavin at 1 mg/kg i.v. prolonged not only the initiation of thrombus, but also the time to occlusion.

• Authors: N Hisamichi, T Kawasaki, K Suzuki, S Kaku, Y Sakai, Y Taniuchi, K Sato, O Inagaki, K Tomioka, I Yanagisawa, T Takenaka, K Yanagi, N Ohshima
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 312 Issue 1 Pg. 69-73 (Sep 19 1996) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8891580 (Publication Type: Journal Article)

Chemical References

• Fibrinolytic Agents
• Peptides
• Platelet Aggregation Inhibitors
• Platelet Glycoprotein GPIIb-IIIa Complex
• Platelet Glycoprotein GPIb-IX Complex
• triflavin
• Aurintricarboxylic Acid

Topics

• Animals
• Aurintricarboxylic Acid (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Synergism
• Drug Therapy, Combination
• Fibrinolytic Agents (pharmacology)
• Male
• Peptides (administration & dosage)
• Platelet Aggregation Inhibitors (administration & dosage)
• Platelet Glycoprotein GPIIb-IIIa Complex (antagonists & inhibitors)
• Platelet Glycoprotein GPIb-IX Complex (antagonists & inhibitors)
• Rats
• Rats, Wistar
• Thrombosis (drug therapy)