The captopril test in children with renovascular and renal hypertension.

Abstract

We used the captopril test (CT) in 32 children, 8 with renovascular hypertension (RVH), 17 with renal hypertension (RH) and 7 with normal blood pressure, in order to study the renin-angiotensin system activation (RASA). All children affected by RVH presented a positive CT: a post-captopril plasma renin activity (PRA) of 12 ng ml-1 h-1 or more, an absolute PRA increase of 10 ng ml-1 h-1 or more and a 150% increase or more, or 400% or more if the baseline PRA was less than 3 ng ml-1 h-1. The CT may be useful for demonstrating the RASA in RVH.

• Authors: E Fossali, R Intermite, M Minoja, S Tirelli, F Sereni
• Journal: Acta paediatrica (Oslo, Norway : 1992) (Acta Paediatr) Vol. 85 Issue 9 Pg. 1129-31 (Sep 1996) ISSN: 0803-5253 [Print] Norway
• PMID: 8888932 (Publication Type: Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Captopril
• Renin

Topics

• Adolescent
• Angiotensin-Converting Enzyme Inhibitors
• Blood Pressure
• Captopril
• Child
• Child, Preschool
• Humans
• Hypertension, Renal (diagnosis, physiopathology)
• Infant
• Renin (blood)
• Renin-Angiotensin System