Carcinoid tumors of the lung: immuno- and ligandohistochemistry, analysis of integrated optical density, syntactic structure analysis, clinical data, and prognosis of patients treated surgically.

Abstract

BACKGROUND:

Analysis of potentially prognostic relevant factors of carcinoid tumors of the lung.

METHODS:

Clinical features, tumor size, and features derived from immuno- and ligandohistochemistry, cytometry and histometry, and survival have been analyzed in 82 potentially curatively resected carcinoid tumors of the lung.

RESULTS:

Patients with typical carcinoid tumors had a longer history of symptoms (13 vs. 8 months), fewer smoked (30% vs. 80%), and developed less frequently lymph node metastases (20% vs. 65%) compared to patients with atypical carcinoids. Statistically significant differences between both cell types have been observed in cytometric and histometric features, and binding of Lewis A trisaccharide (Lea). Prognosis is associated with the cell type, presence of lymph node metastases and heparin-binding lectin (HBL), certain cytometric and structural features, and binding of macrophage migration inhibitory factor (MIF) and beta-N-acetyl-D-galactosamine (beta-GalNAc).

CONCLUSIONS:

Complete lymph node dissection is necessary, data of cytometry, histometry, and ligandohistochemistry might eventually predict the course of the disease.

• Authors: K Kayser, C Kayser, W Rahn, N V Bovin, H J Gabius
• Journal: Journal of surgical oncology (J Surg Oncol) Vol. 63 Issue 2 Pg. 99-106 (Oct 1996) ISSN: 0022-4790 [Print] United States
• PMID: 8888802 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Carcinoid Tumor (metabolism, pathology, surgery)
• Female
• Flow Cytometry
• Gene Expression Regulation, Neoplastic
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Lung Neoplasms (metabolism, pathology, surgery)
• Male
• Middle Aged
• Prognosis
• Survival Analysis