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Possible cytoprotective mechanism in rats of D-002, an anti-ulcerogenic product isolated from beeswax.

Abstract
D-002 is an anti-ulcerogenic product, isolated from beeswax, which consists of a well-defined mixture of higher primary aliphatic alcohols. It is highly effective against ethanol-induced ulcers. This study was designed to determine if D-002 shows cytoprotective properties on gastric mucosa in ethanol-induced ulcers. The involvement of endogenous prostaglandins in the protective effect of D-002 was also investigated. When a subulcerogenic dose of indomethacin (10 mg kg-1) was injected simultaneously with oral administration of ethanol, oral pre-treatment with D-002 (5-100 mg kg-1) partially inhibited the gastric protection. D-002 (5 and 25 mg kg-1) administered to normal rats significantly increased the soluble mucus content and also prevented its reduction in rats with ethanol-induced ulcers. In addition, D-002 administered at 5 and 25 mg kg-1 prevented the increase of vascular permeability induced by ethanol (60%) and reduced the concentration of thromboxane B2 (TXB2) in gastric mucosa of rats with ethanol-induced ulcers. These results support the hypothesis that the anti-ulcerogenic properties of D-002 could be related to a cytoprotective mechanism.
AuthorsD Carbajal, V Molina, S Valdés, L Arruzazabala, I Rodeiro, R Más, J Magraner
JournalThe Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 48 Issue 8 Pg. 858-60 (Aug 1996) ISSN: 0022-3573 [Print] England
PMID8887738 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • D 002
  • Fatty Alcohols
  • Prostaglandins
  • Waxes
  • beeswax
  • Ethanol
  • Thromboxane B2
Topics
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Bees (chemistry)
  • Capillary Permeability (drug effects)
  • Ethanol
  • Fatty Alcohols (isolation & purification, therapeutic use)
  • Female
  • Gastric Mucosa (blood supply, drug effects, metabolism)
  • Mucus (metabolism)
  • Prostaglandins (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Thromboxane B2 (metabolism)
  • Ulcer (chemically induced, prevention & control)
  • Waxes (chemistry)

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