Abstract | OBJECTIVE: STUDY DESIGN: Women with documented idiopathic preterm labor stabilized with acute tocolytic therapy were randomized to three groups: placebo, terbutaline 5 mg, or magnesium chloride 128 mg, all given orally every 4 hours. Patients and providers were blinded to group assignment. All subjects were enrolled in a comprehensive system of preterm birth prevention that included preterm labor education, weekly clinic visits, home uterine contraction assessment, daily phone contact, and 24-hour perinatal nurse access. RESULTS: Of the 248 patients who were randomized, 39 were delivered before discharge and 4 were lost to follow-up, leaving 205 for final analysis: 68 placebo, 72 terbutaline, and 65 magnesium. The terbutaline group had significantly more side effects than the placebo group did. All groups had otherwise similar perinatal outcomes when confounding variables were controlled for. Overall, the three groups had a preterm birth rate < 37 weeks of 55.6% delivery, < 34 weeks of 15.6%, a 20.4% rate of newborn intensive care unit admission, and a mean neonatal length of stay of 6.3 days. CONCLUSIONS:
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Authors | O A Rust, J A Bofill, R M Arriola, M E Andrew, J C Morrison |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 175
Issue 4 Pt 1
Pg. 838-42
(Oct 1996)
ISSN: 0002-9378 [Print] United States |
PMID | 8885732
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tocolytic Agents
- Magnesium Chloride
- Terbutaline
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Topics |
- Administration, Oral
- Birth Rate
- Double-Blind Method
- Female
- Hospitalization
- Humans
- Infant, Newborn
- Infant, Premature
- Intensive Care, Neonatal
- Magnesium Chloride
(administration & dosage, therapeutic use)
- Pregnancy
- Pregnancy Outcome
- Terbutaline
(administration & dosage, therapeutic use)
- Tocolytic Agents
(administration & dosage, therapeutic use)
- Treatment Failure
- Treatment Outcome
- Uterine Contraction
(drug effects)
- Uterine Monitoring
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