Abstract |
Recent studies have shown both association and linkage between a Gly40-Ser mutation in the glucagon receptor gene and NIDDM in French patients with familial NIDDM. This mutation was present in heterozygous form in 4.6% of diabetic probands but only 1% of the French population, suggesting that it was an important risk factor in the development of NIDDM. A total of 348 unrelated Japanese subjects (220 with NIDDM, 53 with impaired glucose tolerance (IGT) and 75 normal subjects) were screened for the presence of the Gly40-Ser mutation. Seventy-two percent of the NIDDM patients and 52% of IGT subjects had a positive family history of NIDDM. The Gly40-Ser mutation, which could be readily detected in a positive control subject, was not found in any of the 348 Japanese subjects studied. Thus, the Gly40-Ser mutation does not play an important role in the pathogenesis of NIDDM in Japanese patients.
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Authors | M Ogata, N Iwasaki, H Ohgawara, S Karibe, Y Omori |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 33
Issue 2
Pg. 71-4
(Jul 1996)
ISSN: 0168-8227 [Print] Ireland |
PMID | 8879960
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Asian People
(genetics)
- Autoradiography
- Diabetes Mellitus, Type 2
(epidemiology, genetics, physiopathology)
- Electrophoresis, Polyacrylamide Gel
- Female
- Gene Frequency
- Glucose Intolerance
(epidemiology, genetics)
- Humans
- Japan
- Male
- Middle Aged
- Mutation
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Receptors, Glucagon
(genetics)
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