Reduction of intestinal apo A-IV mRNA levels in the cirrhotic rat.
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| Abstract |
In the present study, intestinal apo A-IV synthesis was investigated using a carbon tetrachloride (CCl4)-induced cirrhosis rat model. Triglyceride (TG) content in rat cirrhotic liver was increased markedly by 170% (P < 0.001) and apo B was increased by 20% (P < 0.05) compared with control levels. These results reflected the steatotic change in the liver. In contrast, TG levels in the small intestine of cirrhotic rats decreased significantly (P < 0.01). In addition, intestinal apo A-IV (jejunum P < 0.001; ileum P < 0.01) and its mRNA levels (jejunum P < 0.01; ileum P < 0.05) were also reduced. The decreased apo A-IV content in the jejunum was confirmed by immunohistochemical analysis. These results indicate that intestinal apo A-IV synthesis in cirrhosis is suppressed, at least under the condition of an overnight fast. Therefore, decreased intestinal apo A-IV synthesis may relate to the decreased ability to absorb fat in cirrhosis, but a fat-loading study will be necessary to confirm this hypothesis. It is unknown from the present study why serum apo A-IV level is not significantly decreased, despite a reduction in apo A-IV synthesis. The clearance of apo A-IV by the liver may be delayed or apo A-IV synthesis may be rather markedly enhanced during fat absorption in liver cirrhosis.
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| Authors | M Seishima, T Usui, S Naganawa, M Nishimura, H Moriwaki, Y Muto, A Noma |
| Journal | Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 11 Issue 8 Pg. 746-51 (Aug 1996) ISSN: 0815-9319 [Print] Australia |
| PMID | 8872772 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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