HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Evaluation of a pyridopyridazine as a drug with marked antihypertensive properties (author's transl)].

Abstract
Compound BQ 22-708 is a pyridopyridazine with marked antihypertensive effects on experimentally induced hypertension. At this study hemodynamic reactions were controlled in 5 patients with resistent hypertension, two of them with the complication of hypertensive, two of them with the complication of hypertensive crisis, after oral administration of a mean dose of 11 mg BQ 22-708 (range 5 to 15 mg). Mean arterial pressure was reduced by 40 mm Hg. The onset of drug activity occurred 10 to 20 minutes after application. Maximum was reached after 90 to 180 minutes, whereas the antihypertensive effect lasted for about 5 to 6 hours. Peripheral resistance was reduced by about 50%. Heart rate and cardiac output increased. In patients with normal cardiac function stroke volume remained constant, whereas in patients with heart insufficiency an increase occurred. BQ 22-708 led to a slight reduction in pulmonary artery pressure and pulmonary capillary wedge pressure. Right atrial mean pressure remained unchanged. Additional treatment with a beta-adrenergic-blocking-agent or a drug with Ca-antagonistic-activities is indicated for inhibition of BQ-related increase of heart-rate.
AuthorsH U Lehmann, E Witt, H Hochrein
JournalMedizinische Klinik (Med Klin) Vol. 72 Issue 28-29 Pg. 1203-8 (Jul 15 1977) ISSN: 0025-8458 [Print] Germany
Vernacular TitleZur Wirkung eines Pyridopyridazin-Derivats als potentes Antihypertensivum.
PMID887046 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Pyridazines
  • BQ 22-708
Topics
  • Adult
  • Aged
  • Antihypertensive Agents (pharmacology)
  • Blood Pressure (drug effects)
  • Capillaries
  • Cardiac Output (drug effects)
  • Female
  • Heart Failure (complications)
  • Heart Rate (drug effects)
  • Humans
  • Hypertension (complications, drug therapy)
  • Male
  • Middle Aged
  • Pulmonary Artery
  • Pyridazines (administration & dosage, pharmacology, therapeutic use)
  • Vascular Resistance (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: