Kinetics of anti-mannan antibodies useful in confirming invasive candidiasis in immunocompromised patients.

Abstract

In studying the anti-mannan antibodies longitudinally in serial serum samples of three immunocompromised patients, it was observed that anti-mannan antibodies started to increase shortly after the moment that cultures of deep-tissue sites became positive with Candida albicans. The mean anti-mannan antibody titers determined in a group of 36 immunocompromised patients with invasive candidiasis increased within two weeks after the probable onset of invasive candidiasis. In contrast, anti-mannan antibody levels in serial serum samples of 14 immunocompromised patients who were only colonized with C. albicans remained stable or decreased over time. The HA test measuring the anti-mannan antibodies was 64% sensitive and 89% specific in determining invasive candidiasis. In contrast, antibodies specific for candidal cytoplasmic antigens or enolase alone were of little value in confirming invasive candidiasis in these immunocompromised patients.

• Authors: A J van Deventer, W H Goessens, J H van Zeijl, J W Mouton, M F Michel, H A Verbrugh
• Journal: Microbiology and immunology (Microbiol Immunol) Vol. 40 Issue 2 Pg. 125-31 ( 1996) ISSN: 0385-5600 [Print] Australia
• PMID: 8867608 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Fungal
• Antigens, Fungal
• Mannans
• Reagent Kits, Diagnostic

Topics

• Adolescent
• Adult
• Antibodies, Fungal (blood, immunology)
• Antigens, Fungal (blood, immunology)
• Candida albicans (immunology, isolation & purification)
• Candidiasis (blood, drug therapy, immunology, microbiology)
• Counterimmunoelectrophoresis
• Fatal Outcome
• Female
• Humans
• Immunocompromised Host (immunology)
• Kinetics
• Male
• Mannans (analysis, immunology)
• Reagent Kits, Diagnostic