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Distinct effects of N omega-nitro-L-arginine on seizures induced by several drugs in mice.

Abstract
A potent nitric oxide (NO) synthase inhibitor, N omega-nitro-L-arginine (L-NA), suppressed tonic seizure elicited by pentylenetetrazol (PTZ; 100 mg/kg, SC) in a dose-related manner (25 to 100 mg/kg, IP), but had no effect on clonic seizure. The effect was most potent at 1 h after the administration of L-NA. L-NA (100 mg/kg, IP) suppressed clonic seizure as well as tonic seizure in bicuculline-treated (3.0 or 4.5 mg/kg, SC) mice. However, it did not affect seizures elicited by picrotoxin (2.0 to 6.0 mg/kg, SC). On the other hand, N-methyl-DL-aspartate (NMDLA; 300 mg/kg or 350 mg/kg, IP) induced clonic seizure, but tonic seizure was not always noted. All mice with clonic and tonic seizures died, and some mice with clonic seizure died without accompanying tonic seizure. L-NA did not influence NMDLA-induced seizures, but it appeared to enhance NMDLA lethality, though without statistical significance. These findings suggest distinct roles of NO in seizures induced by different drugs in mice.
AuthorsS Hara, F Kuriiwa, N Iwata, T Mukai, S Kano, T Endo
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 53 Issue 3 Pg. 673-7 (Mar 1996) ISSN: 0091-3057 [Print] United States
PMID8866971 (Publication Type: Journal Article)
Chemical References
  • Picrotoxin
  • Arginine
  • Pentylenetetrazole
  • Bicuculline
Topics
  • Animals
  • Arginine (analogs & derivatives, pharmacology)
  • Bicuculline (pharmacology)
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, Inbred ICR
  • Pentylenetetrazole (pharmacology)
  • Picrotoxin (pharmacology)
  • Seizures (chemically induced)
  • Time Factors

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