Abstract |
A potent nitric oxide ( NO) synthase inhibitor, N omega-nitro-L-arginine (L-NA), suppressed tonic seizure elicited by pentylenetetrazol (PTZ; 100 mg/kg, SC) in a dose-related manner (25 to 100 mg/kg, IP), but had no effect on clonic seizure. The effect was most potent at 1 h after the administration of L-NA. L-NA (100 mg/kg, IP) suppressed clonic seizure as well as tonic seizure in bicuculline-treated (3.0 or 4.5 mg/kg, SC) mice. However, it did not affect seizures elicited by picrotoxin (2.0 to 6.0 mg/kg, SC). On the other hand, N-methyl-DL-aspartate (NMDLA; 300 mg/kg or 350 mg/kg, IP) induced clonic seizure, but tonic seizure was not always noted. All mice with clonic and tonic seizures died, and some mice with clonic seizure died without accompanying tonic seizure. L-NA did not influence NMDLA-induced seizures, but it appeared to enhance NMDLA lethality, though without statistical significance. These findings suggest distinct roles of NO in seizures induced by different drugs in mice.
|
Authors | S Hara, F Kuriiwa, N Iwata, T Mukai, S Kano, T Endo |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 53
Issue 3
Pg. 673-7
(Mar 1996)
ISSN: 0091-3057 [Print] United States |
PMID | 8866971
(Publication Type: Journal Article)
|
Chemical References |
- Picrotoxin
- Arginine
- Pentylenetetrazole
- Bicuculline
|
Topics |
- Animals
- Arginine
(analogs & derivatives, pharmacology)
- Bicuculline
(pharmacology)
- Dose-Response Relationship, Drug
- Male
- Mice
- Mice, Inbred ICR
- Pentylenetetrazole
(pharmacology)
- Picrotoxin
(pharmacology)
- Seizures
(chemically induced)
- Time Factors
|