Cyclophosphamide in the treatment of toxic epidermal necrolysis.

Abstract

A patient with non-small cell lung carcinoma and recent radiotherapy for brain metastases developed toxic epidermal necrolysis (TEN) shortly after therapy with phenytoin was initiated for a seizure. Exfoliation progressed to involve 90% of her body surface despite treatment with high-dose corticosteroids for 5 days, but sloughing and systemic toxicity ceased within 2 days of initiating therapy with intravenous cyclophosphamide (300 mg/day). Reepithelialization rapidly followed. This experience and the reports of others suggest that intravenous cyclophosphamide is helpful in the treatment of TEN.

• Authors: N G Frangogiannis, I Boridy, M Mazhar, R Mathews, S Gangopadhyay, T Cate
• Journal: Southern medical journal (South Med J) Vol. 89 Issue 10 Pg. 1001-3 (Oct 1996) ISSN: 0038-4348 [Print] United States
• PMID: 8865797 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Immunosuppressive Agents
• Phenytoin
• Cyclophosphamide

Topics

• Adult
• Anticonvulsants (adverse effects)
• Body Surface Area
• Brain Neoplasms (radiotherapy, secondary)
• Carcinoma, Non-Small-Cell Lung (radiotherapy, secondary)
• Cyclophosphamide (administration & dosage, therapeutic use)
• Disease Progression
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Injections, Intravenous
• Lung Neoplasms (pathology)
• Phenytoin (adverse effects)
• Skin (physiopathology)
• Stevens-Johnson Syndrome (drug therapy, etiology, physiopathology)
• Wound Healing