Chemokine receptors: structure, function and role in microbial pathogenesis.

Abstract

The chemokine superfamily is composed of at least 20 different leukocyte chemoattractants that act by binding to a family of G protein-coupled receptors. Leukocyte subtypes respond preferentially to unique but overlapping subsets of chemokines as determined by the receptor distribution, yet the receptors appear to signal through a common Gi-type G protein. Since chemokines appear to play major roles in inflammatory pathology, their receptors may be good targets for developing leukocyte selective anti-inflammatory drugs. Two chemokine receptors, CC CKRS and ONCC, function pathologically as cell entry factors respectively for human immunodeficiency virus 1, the cause of AIDS, and Plasmodium vivax, the major cause of malaria.

• Authors: P M Murphy
• Journal: Cytokine & growth factor reviews (Cytokine Growth Factor Rev) Vol. 7 Issue 1 Pg. 47-64 (Jun 1996) ISSN: 1359-6101 [Print] England
• PMID: 8864354 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Cytokine

Topics

• Amino Acid Sequence
• Animals
• Bacterial Infections (physiopathology)
• Humans
• Molecular Sequence Data
• Multigene Family
• Protein Structure, Secondary
• Receptors, Cytokine (chemistry, genetics, physiology)
• Sequence Homology, Amino Acid
• Structure-Activity Relationship
• Virus Diseases (physiopathology)