Pemoline-induced autoimmune hepatitis.

Abstract

We present a case of pemoline-induced autoimmune hepatitis in a 46-yr-old woman who received the drug for management of her multiple sclerosis. The autoimmune nature of the hepatitis is based on elevation of her anti-nuclear antibodies, anti-thyroid antibodies, IgA, and IgM globulins. These features of autoimmunity disappeared with normalization of her liver-associated enzymes and have remained negative for at least 6 months after completion of prednisone therapy.

• Authors: M J Sterling, M Kane, N D Grace
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 91 Issue 10 Pg. 2233-4 (Oct 1996) ISSN: 0002-9270 [Print] United States
• PMID: 8855756 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Antinuclear
• Autoantibodies
• Central Nervous System Stimulants
• Glucocorticoids
• Immunoglobulin A
• Immunoglobulin M
• Pemoline
• Prednisone

Topics

• Antibodies, Antinuclear (analysis)
• Autoantibodies (analysis)
• Autoimmune Diseases (chemically induced, drug therapy)
• Central Nervous System Stimulants (adverse effects, therapeutic use)
• Chemical and Drug Induced Liver Injury (drug therapy, immunology)
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Immunoglobulin A (analysis)
• Immunoglobulin M (analysis)
• Middle Aged
• Multiple Sclerosis (drug therapy)
• Pemoline (adverse effects, therapeutic use)
• Prednisone (therapeutic use)
• Thyroid Gland (immunology)