[A patient with pancreatic acinar cell carcinoma, effectively treated by the infusion chemotherapy through hepatic artery using 5-FU, CDDP and MMC].

Abstract

Chemotherapy for pancreatic acinar cell carcinoma has not been well studied. We report herein one patient, in whom arterial chemotherapy with 5-FU, CDDP and MMC was extremely effective. He underwent distal pancreatectomy associated with partial resection of transverse colon. Hepatic recurrence was detected by MRI 8 months after the surgery. 5-FU (250 mg/day), CDDP (20 mg/day), and MMC (10 mg) was injected through a catheter introduced into the proper hepatic artery. His tumor became hardly detectable by MRI, and he was discharged about 1 month after admission. 5-FU (250 mg) and CDDP (20 mg) were injected every two weeks, and recurrence was not observed for 5 months.

• Authors: M Sakon, H Osato, S Kishimoto, T Aoki, T Yamada, N Higaki, K Taniguchi, K Sugimoto, K Dohno, K Umeshita, M Gotoh, M Monden
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 23 Issue 11 Pg. 1614-6 (Sep 1996) ISSN: 0385-0684 [Print] Japan
• PMID: 8854820 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Mitomycin
• Cisplatin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Acinar Cell (drug therapy)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Fluorouracil (administration & dosage)
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Male
• Middle Aged
• Mitomycin (administration & dosage)
• Pancreatic Neoplasms (drug therapy)