[Study of hepatic arterial chemoinfusion with continuous CDDP, 5-FU low dose administration for advanced gallbladder cancer].

Abstract

Eight unresectable cases of gallbladder cancer underwent hepatic-artery infusion (HAI) with a consequent combination of cisplatin (CDDP) and 5-fluorouracil (5-FU) administration at a continuous low dose. Five cases (62.5%) showed a partial response (PR). Median survival time was 481.9 days. Cytoreductive surgery was performed in three patients of PR. One case has been disease free and alive over 52 months postoperatively. Gallbladder cancer is well known as a chemoresistant cancer, whereas the higher response rate and the longer survival were achieved with HAI. These results suggested CDDP, 5-FU HAI is a useful chemotherapy for advanced gallbladder cancer, and it is also worthwhile to introduce the preoperative down-staging for consequent cytoreduction surgery.

• Authors: S Fukuda, K Okuda, H Kinoshita, T Nakayama, M Tanaka, T Yoshida, H Isomoto
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 23 Issue 11 Pg. 1610-3 (Sep 1996) ISSN: 0385-0684 [Print] Japan
• PMID: 8854819 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Fluorouracil (administration & dosage)
• Gallbladder Neoplasms (drug therapy, mortality)
• Hepatic Artery
• Humans
• Infusions, Intra-Arterial
• Middle Aged
• Survival Rate