Adherence enhancers in pill-related clinical trials: a health behavior in cancer prevention model-based approach.

Abstract

Preventing non-adherence and treating adherence failure are important to consider in designing community-based clinical trials. The approach and methods for managing adherence are vital. This paper describes a practical and theoretically-based strategy for managing adherence in a small cancer prevention trial with subjects (n = 40) taking a non-steroidal anti-inflammatory drug, piroxicam. Average daily pill intake adherence was exceptionally high (97.4%) as measured by self-report calendar. Thus, the generalized adherence enhancement approach used in this study may have been a related factor, although statistical model-testing was not possible in this small trial. The generalized intervention took into account factors such as the potential barriers and benefits of being in the study, self-efficacy and satisfaction with the participant/staff relationship. These and other theoretical variables were incorporated into an overall adherence strategy that is discussed.

• Authors: J R Atwood, L Giordano, P Vargas, G G Blackwell, D L Earnest, F Meyskens, D Alberts
• Journal: Patient education and counseling (Patient Educ Couns) Vol. 28 Issue 1 Pg. 15-23 (Jun 1996) ISSN: 0738-3991 [Print] Ireland
• PMID: 8852203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piroxicam

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Clinical Trials as Topic
• Colonic Neoplasms (prevention & control)
• Female
• Health Behavior
• Health Knowledge, Attitudes, Practice
• Humans
• Male
• Middle Aged
• Models, Psychological
• Patient Compliance
• Patient Education as Topic
• Piroxicam (therapeutic use)