Effect of pretreatment with ketorolac tromethamine on post-operative pain following periodontal surgery.

Abstract	A double-blind, randomized, single-dose clinical trial to evaluate the analgesic efficacy of preoperative ketorolac tromethamine administration on periodontal postoperative pain was designed. One group received 20 mg ketorolac immediately before periodontal flap surgery, and the other group received placebo. Naproxen sodium was allowed postoperatively as rescue medication. The visual analog scale was used to estimate pain. Postoperative pain was assessed hourly for the first 10 h on the day of surgery, and 4 x daily on the 1st and 2nd postsurgical days. Timing and dose of rescue analgesic remedication were also recorded. Results indicated that preoperative treatment with ketorolac significantly reduced initial pain intensity and delayed the onset of postoperative pain as compared to placebo. Incidence and amount of naproxen consumption was similarly small in both ketorolac- and placebo-treated groups. No adverse reactions related to preoperative medication were observed.
Authors	L Trombelli, G P Schincaglia, F Zangari, C Scapoli, G Calura
Journal	Journal of clinical periodontology (J Clin Periodontol) Vol. 23 Issue 2 Pg. 128-32 (Feb 1996) ISSN: 0303-6979 [Print] United States
PMID	8849849 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Analgesics Anti-Inflammatory Agents, Non-Steroidal Placebos Tromethamine Ketorolac Tromethamine Naproxen Tolmetin
Topics	Adult Aged Alveoloplasty Analgesics (administration & dosage, adverse effects, therapeutic use) Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use) Debridement Double-Blind Method Female Follow-Up Studies Humans Ketorolac Tromethamine Male Middle Aged Naproxen (administration & dosage, therapeutic use) Pain Measurement Pain, Postoperative (prevention & control) Periodontal Diseases (surgery) Placebos Premedication Surgical Flaps Tolmetin (administration & dosage, adverse effects, analogs & derivatives, therapeutic use) Tooth Root (surgery) Tromethamine (administration & dosage, adverse effects, analogs & derivatives, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!