Healing of chronic antral gastritis: effect of sucralfate and colloidal bismuth subcitrate.

Abstract

BACKGROUND:

Colloidal bismuth subcitrate (CBS) causes endoscopic and histological improvement in gastritis and eradication of Helicobacter pylori in patients with non-ulcer dyspepsia (NUD). The effect of sucralfate, a cytoprotective drug, on endoscopic and histologic gastritis and H pylori clearance is not clear. We studied the effect of CBS and sucralfate on these features in patients with NUD.

METHODS:

Sixty three patients with NUD and H pylori infection were randomized to receive one of the following for four weeks: (i) CBS (240 mg twice daily) (Group 1); (ii) placebo I, similar in size, color and shape to CBS (Group 2); (iii) sucralfate (2.0 g twice daily) (Group 3) and (iv) placebo II, similar to sucralfate (Group 4). Symptoms, endoscopic and histological findings and H pylori status were assessed before and after treatment.

RESULTS:

Similar symptomatic improvement was observed with each treatment, indicating a placebo effect. Significant endoscopic and histological improvement was observed with CBS only. CBS was better than sucralfate in inducing endoscopic and histological improvement. Clearance rate of H pylori was 46.6% with CBS, 16.6% with its placebo, 33.3% with sucralfate and 13.3% with its placebo.

CONCLUSION:

CBS is more effective than sucralfate in inducing endoscopic and histologic healing of H pylori-related gastritis among NUD patients.

• Authors: M Kumar, S K Yachha, R Aggarwal, S Shukla, R Pandey, K N Prasad, A Ayyagari, S R Naik
• Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology (Indian J Gastroenterol) Vol. 15 Issue 3 Pg. 90-3 (Jul 1996) ISSN: 0254-8860 [Print] India
• PMID: 8840633 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Organometallic Compounds
• Sucralfate
• bismuth tripotassium dicitrate

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Anti-Ulcer Agents (therapeutic use)
• Dyspepsia (drug therapy, microbiology)
• Female
• Gastritis (drug therapy, microbiology)
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Male
• Organometallic Compounds (therapeutic use)
• Sucralfate (therapeutic use)