HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Clinical effectiveness of an ointment containing prostaglandin E1 for the treatment of burn wounds.

Abstract
This report discusses the effectiveness of conservative treatment of burns using applications of prostaglandin E1 (PGE1) containing ointment (PGE1 ointment) to the wound site. Fourteen patients with superficial dermal burns (SDB), deep dermal burns (DDB) and full-thickness dermal burns (DB), who were treated with repeated applications of this ointment, showed rapid epithelialization of the affected tissue. Hypertrophic scarring after epithelialization was less than that expected after other therapies. The degree of scarring was graded as 'none', 'mild', 'moderate' or 'severe'. The results of this therapy revealed no scarring in two sites (8.7 per cent), mild scarring in 16 sites (69.6 per cent), moderate scarring in one site (4.3 per cent) and severe scarring in four sites (17.4 per cent) out of 23 sites distributed among the patients. The application of PGE1 ointment in combination with skin grafting surgery was found to improve functional and aesthetic results in the patients with DDB and DB, by minimizing the area of the donor site; it was especially useful for children with extensive burns because of the shortage of available tissue as donor site material for skin grafting.
AuthorsH Gunji, I Ono, T Tateshita, F Kaneko
JournalBurns : journal of the International Society for Burn Injuries (Burns) Vol. 22 Issue 5 Pg. 399-405 (Aug 1996) ISSN: 0305-4179 [Print] Netherlands
PMID8840042 (Publication Type: Case Reports, Clinical Trial, Journal Article)
Chemical References
  • Alprostadil
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Alprostadil (administration & dosage, therapeutic use)
  • Burns (drug therapy, pathology)
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Treatment Outcome
  • Wound Healing (drug effects, physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: