Effects of estrone with or without medroxyprogesterone acetate on the femur in aged rats.

Abstract

In an attempt to define the efficacy of hormone replacement therapy in postmenopausal osteoporosis, we investigated the effects of estrone with or without medroxyprogesterone acetate on the bone mineral density of the femur of aged rats, of which plasma levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and estradiol were markedly reduced in comparison with those of younger rats. Although additional sex hormones had little effect on the plasma levels of gonadotropins, chronic administration of estrone significantly enhanced the bone mineral density of femur in aged animals.

• Authors: S Sassa, H Shinoda, H Kudo, S Suzuki, K Kuwa, S Yoshimura, M Maemura, T Nakayama, T Mitamura, S Sakamoto
• Journal: In vivo (Athens, Greece) (In Vivo) 1996 Jul-Aug Vol. 10 Issue 4 Pg. 455-7 ISSN: 0258-851X [Print] Greece
• PMID: 8839794 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Estrone
• Luteinizing Hormone
• Follicle Stimulating Hormone
• Medroxyprogesterone Acetate

Topics

• Aging
• Animals
• Bone Density
• Estrone (pharmacology)
• Female
• Femur (drug effects, metabolism)
• Follicle Stimulating Hormone (blood)
• Luteinizing Hormone (blood)
• Medroxyprogesterone Acetate (pharmacology)
• Organ Size
• Rats
• Rats, Sprague-Dawley