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The role of glutamic acid in the pathogenesis of stroke and the development of neuroprotective drugs.

Abstract
The role of glutamic acid (glutamate) in the pathogenesis of stroke is now fairly well established. As a result, many drugs which act on glutamate receptors are currently under investigation for their ability to prevent the damage induced by glutamate under ischaemic conditions. The efficacy of these compounds in protecting central neurones from the effects of stroke may be indicative of the importance of the role that glutamate plays in this process.
AuthorsS M Evans, J I Addae
JournalThe West Indian medical journal (West Indian Med J) Vol. 44 Issue 4 Pg. 119-23 (Dec 1995) ISSN: 0043-3144 [Print] Jamaica
PMID8838047 (Publication Type: Journal Article, Review)
Chemical References
  • Neuroprotective Agents
  • Receptors, Glutamate
  • Glutamic Acid
Topics
  • Brain Damage, Chronic (physiopathology, prevention & control)
  • Cerebrovascular Disorders (drug therapy, physiopathology)
  • Glutamic Acid (physiology)
  • Humans
  • Neuroprotective Agents (therapeutic use)
  • Receptors, Glutamate (drug effects, physiology)

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