Abstract | BACKGROUND & AIMS: METHODS: RESULTS: In patients from group II, hypercholesterolemia was associated with increased levels of high-density lipoprotein and high concentrations of apoAI and apoAII; in a few cases, an abnormal lipoprotein with a slow alpha migration was observed. In contrast, in patients from group I, the levels of high-density lipoprotein cholesterol and apoAI and apoAII were very low, and the abnormal lipoprotein X was in many cases responsible for hypercholesterolemia. In group I, the decreased LCAT activity was consistent with the very high level of unesterified cholesterol and the emergence of lipoprotein X. In both groups of patients, the levels of apoE, apoCII, and apoCIII were high, and all the lipoprotein fractions were enriched in phospholipids. CONCLUSIONS:
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Authors | A Davit-Spraul, M L Pourci, V Atger, M Cambillau, M Hadchouel, N Moatti, A Legrand |
Journal | Gastroenterology
(Gastroenterology)
Vol. 111
Issue 4
Pg. 1023-32
(Oct 1996)
ISSN: 0016-5085 [Print] United States |
PMID | 8831598
(Publication Type: Journal Article)
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Chemical References |
- Apolipoproteins
- Cholesterol, HDL
- Lipoproteins
- Phosphatidylcholine-Sterol O-Acyltransferase
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Topics |
- Adolescent
- Adult
- Alagille Syndrome
(blood)
- Apolipoproteins
(blood)
- Child
- Child, Preschool
- Cholesterol, HDL
(blood)
- Female
- Humans
- Infant
- Jaundice
(blood)
- Lipoproteins
(blood)
- Male
- Phosphatidylcholine-Sterol O-Acyltransferase
(metabolism)
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