Abstract |
In the present study, the anticonflict effect of diazepam was significantly abolished by pretreatment with naloxone, beta-funaltrexamine or nor-binaltorphimine but not naltrindole, using a Vogel-type conflict paradigm in mice. However, naloxone alone had a significant proconflict effect, and beta-funaltrexamine alone tended to produce a proconflict effect. Spontaneous drinking behavior was not affected by treatment with diazepam and nor-binaltorphimine. In addition, nor-binaltorphimine had no effect on diazepam-induced motor incoordination, hypothermia or anticonvulsant action, respectively. Moreover, the stable dynorphin analog E2078 ([N-methyl-Tyr1, N-alpha-methyl-Arg7-D-Leu8] dynorphin A-(1-8) ethylamide) and the highly selective kappa-opioid receptor agonist U50,488H (trans-3,4-dichloro-N-(2-(1-pyrrolidinyl)cyclohexyl)benzenacetamide++ + methanesulfonate hydrochloride) produced a significant anticonflict effect, which was completely antagonized by pretreatment with nor-binaltorphimine. These findings suggested that the kappa- opioid system may play an important role in the anxiolytic effect of benzodiazepine and the regulation of anxiety.
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Authors | M Tsuda, T Suzuki, M Misawa, H Nagase |
Journal | European journal of pharmacology
(Eur J Pharmacol)
Vol. 307
Issue 1
Pg. 7-14
(Jun 20 1996)
ISSN: 0014-2999 [Print] Netherlands |
PMID | 8831097
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Anti-Anxiety Agents
- Anticonvulsants
- Narcotic Antagonists
- Peptide Fragments
- Receptors, Opioid
- Receptors, Opioid, kappa
- E 2078
- norbinaltorphimine
- Naltrexone
- Dynorphins
- Diazepam
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Topics |
- Analgesics, Non-Narcotic
(pharmacology)
- Animals
- Anti-Anxiety Agents
(antagonists & inhibitors, pharmacology)
- Anticonvulsants
(pharmacology)
- Body Temperature
(drug effects)
- Conflict, Psychological
- Diazepam
(antagonists & inhibitors, pharmacology)
- Drug Interactions
- Dynorphins
(pharmacology)
- Male
- Mice
- Mice, Inbred Strains
- Motor Activity
(drug effects)
- Naltrexone
(analogs & derivatives, pharmacology)
- Narcotic Antagonists
(pharmacology)
- Peptide Fragments
(pharmacology)
- Receptors, Opioid
(drug effects, physiology)
- Receptors, Opioid, kappa
(agonists)
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