Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-matched allogeneic bone marrow transplantation.

Abstract	BUF rats suffering from severe relapsing experimental autoimmune encephalomyelitis (R-EAE), a model for multiple sclerosis, were treated with intensive cytoreductive therapy and grafting of allogeneic bone marrow (BM). BN.1B rats were used as EAE-resistant, largely MHC-matched donors, resembling human BMT from HLA-identical siblings. The treatment induces complete remission and low recurrence rates of R-EAE. Evidence is provided that the efficacy of the treatment depends on a high degree of lymphoablation: a minority of rats had host-type residual activated T lymphocytes in the CNS after treatment. Furthermore, complete replacement of host-type BM by donor-type hemopoietic cells is essential, as higher relapse rates were observed in animals with incomplete reconstitution by donor cells than in completely reconstituted rats. Overall, our results indicate that patients with severe MS might benefit from treatment with HLA-matched allogeneic BM.
Authors	M van Gelder, A H Mulder, D W van Bekkum
Journal	Transplantation (Transplantation) Vol. 62 Issue 6 Pg. 810-8 (Sep 27 1996) ISSN: 0041-1337 [Print] United States
PMID	8824482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Monoclonal Histocompatibility Antigens histocompatibility antigens RT, rat Cyclophosphamide Busulfan
Topics	Animals Antibodies, Monoclonal (immunology, pharmacology) Bone Marrow Transplantation Busulfan Cyclophosphamide Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental (therapy) Graft vs Host Reaction Histocompatibility Histocompatibility Antigens (immunology) Lymphocyte Depletion Multiple Sclerosis Radiation Chimera Rats Rats, Inbred BN Rats, Inbred BUF Recurrence Remission Induction T-Lymphocytes, Cytotoxic (immunology) Transplantation Conditioning Transplantation, Homologous Whole-Body Irradiation

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