Transient diabetes insipidus in pregnancy--a consequence of enhanced placental clearance of arginine vasopressin.

Abstract

We report a patient who presented with transient diabetes insipidus in pregnancy on a background of previous postoperative diabetes insipidus following surgical excision of a prolactinoma. The patient illustrates how the complex changes in water homeostasis occurring during normal pregnancy may unmask latent diabetes insipidus. The major factors operating appear to be a physiological reduction in the thresholds for thirst and arginine vasopressin secretion coupled with a substantial increase in placental clearance of arginine vasopressin. Reversal of these changes after delivery results in normalization of the disordered water homeostasis, with consequent resolution of the diabetes insipidus.

• Authors: S G Soule, J P Monson, H S Jacobs
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 10 Issue 12 Pg. 3322-4 (Dec 1995) ISSN: 0268-1161 [Print] England
• PMID: 8822468 (Publication Type: Case Reports, Journal Article)

Chemical References

• Arginine Vasopressin

Topics

• Adult
• Arginine Vasopressin (metabolism)
• Body Water (metabolism)
• Diabetes Insipidus (complications, metabolism)
• Female
• Homeostasis
• Humans
• Pituitary Neoplasms (complications, surgery)
• Placenta (metabolism)
• Pregnancy
• Pregnancy in Diabetics (etiology, metabolism)
• Prolactinoma (complications, surgery)