[Infiltrating transitional carcinoma of the bladder. (1st part). Preoperative or neoadjuvant chemotherapy. Our experience with 38 patients followed-up for a prolonged period].
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| Abstract |
Analysis of the evolution of 37 patients treated with neoadjuvant chemotherapy + radical cystectomy and bilateral lymphadenectomy. Patients were followed until death, and survivors between 43 and 68 months. Twenty-six patients died. Twenty of them within 24 months after treatment and 6 after 2 years. Five did not undergo surgery due to fast tumour progression during the interval scheduled for cytostatics administration. Bladder removal was rejected in 5 cases after a significant loco-regional progression was shown by laparotomy. Initially, bladder was preserved in 12 patients after TUR + chemotherapy, and in 8 patients when cCR was observed: 1 died due to a disease unrelated cause. 1 was lost after 16 months with no evidence of vesical cancer or metastasis. 3 presented distant dissemination. 3 are alive and have no evidence of tumour. 1 pCR died of metastasis. 1 cPR required radical cystectomy and died of metastasis. Of the 2 cases defined as sCR, one had to undergo radical cystectomy and remains disease-free while the other one died of metastasis. Radical cystectomy was performed in 15 cases. Three remain tumour-free, 2 were lost. to follow-up and 10 died (3 for disease-unrelated causes and 7 as a consequence of their condition). Nodes affectation were present in 54%. Metastasis was found in 57.3% and 17.3% had local relapse. The pre-operative chemotherapy regime examined has not contributed to prolong the metastasis-free interval in the group of patients studied.
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| Authors | A Escudero Barrilero, E Fernández, C Crespo |
| Journal | Actas urologicas espanolas (Actas Urol Esp) Vol. 19 Issue 4 Pg. 294-302 (Apr 1995) ISSN: 0210-4806 [Print] Spain |
| Vernacular Title | Carcinoma transicional infiltrante de vejiga. (1a parte). Quimioterapia preoperatoria o neoadyuvante. Nuestra experiencia con 38 enfermos con seguimiento prolongado. |
| PMID | 8815654 (Publication Type: Clinical Trial, English Abstract, Journal Article) |
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