A double blind, placebo controlled, crossover trial of D-ribose in McArdle's disease.

Abstract

To determine whether seven days oral D-ribose would improve exercise tolerance in a group of 5 patients with McArdle's disease, we performed a double blind placebo controlled crossover trial. Subjects performed weekly treadmill exercise tests with expired gas analysis until their times were reproducible. They then received 60 g D-ribose daily or placebo for seven days. Exercise testing was repeated on completion of this period. A seven day washout period then followed. Subjects then performed a new baseline exercise test prior to starting the other solution. Again after seven days the exercise test was repeated. There was no significant difference between pre-treatment exercise tests for peak oxygen consumption or level of leg fatigue. Patients did not like taking the ribose and D-Ribose does not appear to be of benefit to patients with McArdle's disease.

• Authors: I C Steele, V H Patterson, D P Nicholls
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 136 Issue 1-2 Pg. 174-7 (Mar 1996) ISSN: 0022-510X [Print] Netherlands
• PMID: 8815168 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Ribose

Topics

• Adult
• Cross-Over Studies
• Double-Blind Method
• Exercise (physiology)
• Exercise Test
• Female
• Glycogen Storage Disease Type V (blood, drug therapy)
• Humans
• Male
• Middle Aged
• Muscle Fatigue (physiology)
• Oxygen Consumption (drug effects, physiology)
• Ribose (therapeutic use)