Abstract | AIMS: METHODS: Both treatment modalities were administered on a five times daily basis to patients suffering from herpes simplex keratitis. Patients were assigned randomly to one of the two treatment groups for the purpose of the trial. They were then examined on days 2, 7, 10, and 14 to assess the rate of healing of the dendritic ulceration. RESULTS: There was no statistically significant difference detected in the rate of healing between the two treatment groups over the course of the trial. CONCLUSIONS: Review of the relative efficacy of topical ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis showed that both treatment modalities were equally effective in their ability to heal the viral induced corneal ulceration. There were no significant side effects or adverse effects reported for either treatment modality.
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Authors | H B Hoh, C Hurley, C Claoue, M Viswalingham, D L Easty, P Goldschmidt, L M Collum |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 80
Issue 2
Pg. 140-3
(Feb 1996)
ISSN: 0007-1161 [Print] England |
PMID | 8814744
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Antiviral Agents
- Gels
- Ointments
- Ganciclovir
- Acyclovir
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Topics |
- Acyclovir
(administration & dosage, therapeutic use)
- Administration, Topical
- Adult
- Aged
- Aged, 80 and over
- Antiviral Agents
(administration & dosage, therapeutic use)
- Female
- Ganciclovir
(administration & dosage, therapeutic use)
- Gels
- Humans
- Keratitis, Dendritic
(drug therapy)
- Male
- Middle Aged
- Ointments
- Prospective Studies
- Treatment Outcome
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