Abstract | OBJECTIVE: DESIGN: SETTING: Aberdeen Royal Infirmary. PARTICIPANTS: Tow hundred and four women with dysfunctional uterine bleeding who, when recruited to the initial study two years previously, were aged less than 50 years, weighed less than 100 kg, and who would otherwise have undergone hysterectomy. RESULTS: Of the 204 women originally recruited, 101 re-attended the clinic and underwent cystometry and follicle stimulating hormone estimation. These, together with a further 59 women, completed postal questionnaires (79% of original cohort). Rates of stress incontinence (44% vs 44%, 95% CI of difference -16% to +15%), urge incontinence (21% vs 19% 95% CI of difference -11% to +14%), and hot flushes (30% vs 44%, 95% CI of difference -25% to +7%) were similar in the hysterectomy and endometrial ablation groups, respectively. Cystometry revealed 14 (31%) cases of bladder dysfunction after hysterectomy and 17 (35%) after hysteroscopic surgery (95% CI of difference -23% to +15%). Serum follicle stimulating hormone levels > 40 IU/L [corrected] were found in three (6%) women following hysterectomy and five (10%) of women after endometrial ablation. CONCLUSION: This study suggests that in comparison with endometrial ablation, simple hysterectomy for dysfunctional uterine bleeding does not compromise bladder or ovarian function, at least at two years after the operation. Due to lack of power the estimates of any differences are imprecise, and clinically significant effects cannot be ruled out.
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Authors | S Bhattacharya, J Mollison, S Pinion, D E Parkin, D R Abramovich, P Terry, H C Kitchener |
Journal | British journal of obstetrics and gynaecology
(Br J Obstet Gynaecol)
Vol. 103
Issue 9
Pg. 898-903
(Sep 1996)
ISSN: 0306-5456 [Print] England |
PMID | 8813310
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Follicle Stimulating Hormone
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Topics |
- Adult
- Climacteric
- Cohort Studies
- Endometrium
(surgery)
- Estrogen Replacement Therapy
- Female
- Follicle Stimulating Hormone
(blood)
- Follow-Up Studies
- Humans
- Hysterectomy
(adverse effects)
- Laser Therapy
(adverse effects)
- Ovarian Diseases
(etiology)
- Patient Satisfaction
- Prospective Studies
- Treatment Outcome
- Urinary Bladder Diseases
(etiology)
- Urinary Incontinence
(etiology)
- Uterine Hemorrhage
(surgery)
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