Anti-oxidant therapy has been effective for treatment of experimental
shock. In this study, the efficacy of
Trolox (Aldrich Chemical Co., Milwaukee, WI), a water-soluble
vitamin E analogue, and
ascorbic acid (
vitamin C) was evaluated in a rat model of
hemorrhagic shock and
resuscitation. In two prospective trials, rats were phlebotomized (27 mL/kg) and left in
shock for 45 minutes.
Resuscitation was then instituted by continuous IV infusion with
lactated Ringer's (LR) (54 mL/kg) over 60 min. In Trial 1, rats were randomized to receive either placebo (LR) or
Trolox (50 mg/kg) in LR. In Trial 2, rats were randomized to LR alone or
ascorbic acid (50 mg/kg) in LR. Survival for
ascorbic acid-treated rats (35 per cent) was not different than for control rats (35 per cent). However, the addition of
Trolox to infusion significantly improved 72 hour survival, 75 per cent versus 40 per cent respectively, for
Trolox-treated and control animals. These data demonstrate that
Trolox is of survival benefit when added to
resuscitation in this model. This benefit does not appear to be related to blood pressure or white cell adhesion.
Trolox is more effective than
ascorbic acid in this model.