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Pulse cyclophosphamide in the treatment of neuropsychiatric systemic lupus erythematosus.

AbstractOBJECTIVE:
The effect of pulse cyclophosphamide treatment was retrospectively assessed in 25 systemic lupus erythematosus (SLE) patients with central nervous system involvement. All patients who tested positive for anti-phospholipid antibodies and/or lupus anticoagulant were excluded.
RESULTS:
Low-dose intravenous cyclophosphamide pulses (500 mg) were administered weekly in all patients. Twenty-four out of 25 patients attained a good response (after a mean of 11 days). Cyclophosphamide was well tolerated in all patients with only minor side effects. None of the patients experienced ovarian failure, cystitis or herpes zoster.
CONCLUSIONS:
Weekly low-dose cyclophosphamide pulses appear to be safe and effective for the management of neuropsychiatric manifestations in SLE patients without antiphospholipid antibodies.
AuthorsP C Ramos, M J Mendez, P R Ames, M A Khamashta, G R Hughes
JournalClinical and experimental rheumatology (Clin Exp Rheumatol) 1996 May-Jun Vol. 14 Issue 3 Pg. 295-9 ISSN: 0392-856X [Print] Italy
PMID8809444 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antirheumatic Agents
  • Cyclophosphamide
Topics
  • Adolescent
  • Adult
  • Antirheumatic Agents (administration & dosage, adverse effects)
  • Child
  • Cyclophosphamide (administration & dosage, adverse effects)
  • Drug Administration Schedule
  • Female
  • Humans
  • Injections, Intravenous
  • Lupus Erythematosus, Systemic (drug therapy)
  • Male
  • Mental Disorders (drug therapy)
  • Middle Aged
  • Neurocognitive Disorders (drug therapy)
  • Retrospective Studies
  • Treatment Outcome

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