Abstract | PURPOSE: MATERIALS AND METHODS: Three groups of subjects participated in this trial of NMP22: 1-175 with transitional cell carcinoma, 2-117 with benign urinary tract conditions and 3-375 healthy volunteers. Each subject provided a single (3 voids) urine sample for analysis at the time of study entry. Each sample was assayed for the level of NMP22. RESULTS: In normal healthy volunteers and in subjects with benign conditions median NMP22 levels were 2.9 and 3.3 units per ml., respectively. Median urinary NMP22 levels in patients with transitional cell carcinoma were significantly greater than in comparison subjects. Patients with active transitional cell carcinoma had significantly greater median urinary NMP22 levels than those with no evidence of disease (6.04 versus 4.11 units per ml., p = 0.027, 1-tailed Mann-Whitney U test). We noted no effect of tumor grade, extent of disease or exposure to intravesical therapy on urinary NMP22 levels. CONCLUSIONS:
|
Authors | G A Carpinito, W M Stadler, J V Briggman, G W Chodak, P A Church, D L Lamm, P H Lange, E M Messing, R M Pasciak, G B Reservitz, R N Ross, D B Rukstalis, M F Sarosdy, M S Soloway, R P Thiel, N Vogelzang, C L Hayden |
Journal | The Journal of urology
(J Urol)
Vol. 156
Issue 4
Pg. 1280-5
(Oct 1996)
ISSN: 0022-5347 [Print] United States |
PMID | 8808854
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- Nuclear Proteins
- nuclear matrix protein 22
|
Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(urine)
- Carcinoma, Transitional Cell
(pathology, therapy, urine)
- Female
- Humans
- Male
- Middle Aged
- Nuclear Proteins
(urine)
- Prospective Studies
- Urologic Neoplasms
(pathology, therapy, urine)
|