Abstract | AIM: METHODS: This two-phase, randomized, double-blind, placebo-controlled, multicentre study consisted of a 4-week treatment phase followed by a 24-week post-treatment observation phase. Patients with an active duodenal ulcer were treated with either ranitidine bismuth citrate 400 mg b.d. for 4 weeks plus clarithromycin 500 mg t.d.s. for the first 2 weeks; ranitidine bismuth citrate 400 mg b.d. for 4 weeks plus placebo t.d.s. for first 2 weeks; placebo b.d. for 4 weeks plus clarithromycin 500 mg t.d.s. for the first 2 weeks; or placebo b.d. for 4 weeks plus placebo t.d.s. for the first 2 weeks. RESULTS: CONCLUSIONS:
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Authors | W L Peterson, A A Ciociola, D L Sykes, D J McSorley, D D Webb |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 10
Issue 3
Pg. 251-61
(Jun 1996)
ISSN: 0269-2813 [Print] England |
PMID | 8791947
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Histamine H2 Antagonists
- ranitidine bismuth citrate
- Ranitidine
- Clarithromycin
- Bismuth
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Anti-Ulcer Agents
(adverse effects, therapeutic use)
- Bismuth
(adverse effects, therapeutic use)
- Clarithromycin
(adverse effects, therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
- Duodenal Ulcer
(drug therapy, microbiology)
- Female
- Helicobacter Infections
(drug therapy, microbiology)
- Helicobacter pylori
- Histamine H2 Antagonists
(adverse effects, therapeutic use)
- Humans
- Male
- Middle Aged
- Patient Compliance
- Ranitidine
(adverse effects, analogs & derivatives, therapeutic use)
- Recurrence
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