HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Antagonism by the 5-HT2A/C receptor agonist DOI of raclopride-induced catalepsy in the rat.

Abstract
It has been shown that the administration of 5-hydroxytryptamine (5-HT)1A receptor agonists will antagonize the catalepsy induced by dopamine D1 or D2 receptor blocking agents. In the present study, administration of the 5-HT2A/C receptor agonist, 1-(2,5-dimethoxy-4-iodo)-2-aminopropane (DOI) (1 mg kg-1 s.c.), counteracted the catalepsy produced by the dopamine D2 receptor antagonist, raclopride (16 mg kg-1 s.c.), but not by the dopamine D1 receptor antagonist (R)-(+)-8-chloro-2,3,4,5-tetra-hydro-3-methyl-5-phenyl-1H-3-benzazepine (SCH 23390) (0.2 mg kg-1 s.c.). The effects of DOI on raclopride-induced catalepsy were fully antagonized by pretreatment with the 5-HT2A/C receptor antagonist, ritanserin (2 mg kg-1 s.c.). The 5-HT precursor, 5-hydroxytryptophan (5-HTP) (6.25-25.0 mg kg-1 i.p.), in combination with the peripheral 5-HTP decarboxylase inhibitor, benserazide (25 mg kg-1 i.p.), and the selective serotonin reuptake inhibitor, zimeldine (10 mg kg-1 s.c.), enhanced the catalepsy produced by a low dose of raclopride (4 mg kg-1 s.c.). It is concluded that stimulation of (postsynaptic) 5-HT2 receptors results in antagonism of the catalepsy induced by treatment with a dopamine D2, but not a D1, receptor antagonist. The fact that 5-HTP, in the presence of benserazide and zimeldine, enhanced raclopride-induced catalepsy suggests the possibility of postsynaptic 5-HT receptors acting in opposition to the 5-HT1 and 5-HT2 receptors, as regards extrapyramidal motor functions in the rat.
AuthorsM L Wadenberg, S Ahlenius
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 294 Issue 1 Pg. 247-51 (Dec 27 1995) ISSN: 0014-2999 [Print] Netherlands
PMID8788438 (Publication Type: Journal Article)
Chemical References
  • Amphetamines
  • Benzazepines
  • Dopamine Agents
  • Dopamine Antagonists
  • Salicylamides
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Serotonin Uptake Inhibitors
  • Ritanserin
  • Zimeldine
  • Raclopride
  • Benserazide
  • 5-Hydroxytryptophan
  • 4-iodo-2,5-dimethoxyphenylisopropylamine
Topics
  • 5-Hydroxytryptophan (pharmacology)
  • Amphetamines (antagonists & inhibitors, pharmacology)
  • Animals
  • Benserazide (pharmacology)
  • Benzazepines (pharmacology)
  • Catalepsy (chemically induced, prevention & control)
  • Dopamine Agents (pharmacology)
  • Dopamine Antagonists (pharmacology)
  • Male
  • Raclopride
  • Rats
  • Rats, Sprague-Dawley
  • Ritanserin (pharmacology)
  • Salicylamides
  • Serotonin Antagonists (pharmacology)
  • Serotonin Receptor Agonists (pharmacology)
  • Selective Serotonin Reuptake Inhibitors (pharmacology)
  • Zimeldine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: