Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: ACAs restricted to the IgA isotype were present in 6 of 10 patients with cutaneous leukocytoclastic vasculitis. IgA ACA levels were significantly higher in these patients than in the control subjects. The presence of IgA ACAs did not correlate with disease severity or involvement of other organs and persisted after resolution of the vasculitis in most patients. In five of the six patients with IgA ACAs, drugs were implicated in the pathogenesis of the vasculitis. By contrast, ACAs were present in only a minority of children with Henoch-Schönlein purpura and adults with IgA nephropathy and were not restricted to the IgA isotype. CONCLUSION:
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Authors | A D Burden, D M Tillman, P Foley, E Holme |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 35
Issue 3 Pt 1
Pg. 411-5
(Sep 1996)
ISSN: 0190-9622 [Print] United States |
PMID | 8784278
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Anticardiolipin
- Autoantibodies
- Immunoglobulin A
- Immunoglobulin Isotypes
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Topics |
- Adult
- Aged
- Antibodies, Anticardiolipin
(blood)
- Autoantibodies
(blood)
- Child
- Enzyme-Linked Immunosorbent Assay
- Female
- Glomerulonephritis, IGA
(blood, immunology)
- Humans
- IgA Vasculitis
(blood, immunology)
- Immunoglobulin A
(blood)
- Immunoglobulin Isotypes
(blood)
- Male
- Middle Aged
- Skin Diseases, Vascular
(blood, immunology)
- Vasculitis, Leukocytoclastic, Cutaneous
(blood, immunology)
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