Styrene and acrylonitrile induced depression of hepatic nonprotein sulfhydryl content in various rodent species.

Abstract

Adult female mice, male rats, female hamsters and male guinea pigs received various doses of styrene (150-1000 mg/kg of body weight) and acrylonitrile (20-80 mg/kg of body weight) intraperitoneally. Both styrene and acrylonitrile caused a depression of the hepatic nonprotein sulfhydryl content. Mouse was the most vulnerable and rat the most resistant species to the effect of both of these two important plastic monomers.

• Authors: H Vainio, A Mäkinen
• Journal: Research communications in chemical pathology and pharmacology (Res Commun Chem Pathol Pharmacol) Vol. 17 Issue 1 Pg. 115-24 (May 1977) ISSN: 0034-5164 [Print] United States
• PMID: 877398 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Nitriles
• Styrenes
• Sulfhydryl Compounds
• Acrylonitrile

Topics

• Acrylonitrile (pharmacology)
• Animals
• Cricetinae
• Depression, Chemical
• Female
• Guinea Pigs
• Liver (drug effects, metabolism)
• Male
• Mesocricetus
• Mice
• Nitriles (pharmacology)
• Rats
• Species Specificity
• Styrenes (pharmacology)
• Sulfhydryl Compounds (metabolism)
• Time Factors