Abstract | PURPOSE: METHODS: A group of 26 patients with resectable gastric cancer were assigned to one of two regimens: UFT alone or UFT plus leucovorin. UFT, equivalent to 400 mg/day tegafur, with or without 30 mg/day leucovorin, was administered orally in divided daily doses every 12 h for 3 consecutive days prior to surgery. Tumor specimens were taken immediately following gastrectomy, and the TS inhibition rate (TSIR) was determined using a ligand-binding assay. RESULTS: The TSIR was significantly higher in the UFT plus leucovorin group than in the UFT alone group (P < 0.01). The TSIR in the patients treated with UFT alone ranged between 14% and 50%, while six of the eight patients treated with UFT plus leucovorin had a TSIR of 55% or higher. The remaining two patients in the group treated with UFT plus leucovorin, with a TSIR of 31% and 44%, had undifferentiated tumors. CONCLUSION: Our results suggest that orally administered low-dose leucovorin can add to the efficacy of UFT in patients with gastric cancer, and provide preliminary data for a randomized clinical trial.
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Authors | T Ichikura, S Tomimatsu, Y Okusa, T Yahara, K Uefuji, S Tamakuma |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 38
Issue 5
Pg. 401-5
( 1996)
ISSN: 0344-5704 [Print] Germany |
PMID | 8765432
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Drug Combinations
- UFT(R) drug
- Tegafur
- Uracil
- Thymidylate Synthase
- Leucovorin
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Topics |
- Administration, Oral
- Aged
- Antimetabolites, Antineoplastic
(pharmacology)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Drug Combinations
- Female
- Humans
- Leucovorin
(administration & dosage)
- Male
- Neoplasm Staging
- Prospective Studies
- Stomach Neoplasms
(drug therapy, enzymology, pathology)
- Tegafur
(administration & dosage)
- Thymidylate Synthase
(antagonists & inhibitors, metabolism)
- Uracil
(administration & dosage)
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