[Combination chemotherapy of 5-fluorouracil and nitrocaphane for the treatment of malignant trophoblastic tumor].

Abstract

OBJECTIVE:

To evaluate the effectiveness, side effects and long term result of combination protocol of 5-fluorouracil (5-FU) and nitrocaphane (AT1258) on patients with malignant trophoblastic tumor.

METHODS:

The chart and follow up data of 166 patients treated from 1979 to 1988 in Liaoning Province Tumor Hospital were reviewed. 136 invasive mole and 30 choriocarcinoma were treated by a 5-FU and AT1258 combined protocol. Their immediate treatment results, side effects and long-term follow-ups were retrospectively analysed.

RESULTS:

The complete remission rate of invasion mole was 100.0% and choriocarcinoma 86.7%. The accumulative 5 and 10 year's survival rate for invasive mole were 100.0% and 99.3%, while 85.8% and 85.8% for choriocarcinoma. None of this group died of side effects or complication.

CONCLUSION:

5-FU and AT1258 combination chemotherapy may be a protocol of choice in the treatment of malignant trophoblastic tumor.

• Authors: L Ju, Y Wang, D Qu
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 31 Issue 4 Pg. 212-5 (Apr 1996) ISSN: 0529-567X [Print] China
• PMID: 8758775 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nitrogen Mustard Compounds
• nitrocaphane
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Choriocarcinoma (drug therapy)
• Female
• Fluorouracil (administration & dosage)
• Follow-Up Studies
• Humans
• Hydatidiform Mole, Invasive (drug therapy)
• Nitrogen Mustard Compounds (administration & dosage)
• Pregnancy
• Retrospective Studies
• Uterine Neoplasms (drug therapy)