Abstract | BACKGROUND: OBJECTIVES: METHODS: We conducted a double-blind, placebo-controlled, parallel-group study in patients who had a history of allergic rhinitis in response to pollens of grass and Parietaria species and were living in northern Italy. After a run-in period of 2 weeks, 24 patients were treated with fluticasone propionate (200 micrograms, once daily), and 26 patients received matched placebo for 6 weeks, starting from the beginning of the pollen season. Assessment of efficacy was based on scores of daily nasal symptoms. Nasal lavage was performed at the end of the season, and differential cell count was expressed as percent of total cells. PD20 methacholine was measured at the beginning and end of the season and after the season had ended. RESULTS: CONCLUSIONS:
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Authors | A Foresi, A Pelucchi, G Gherson, B Mastropasqua, A Chiapparino, R Testi |
Journal | The Journal of allergy and clinical immunology
(J Allergy Clin Immunol)
Vol. 98
Issue 2
Pg. 274-82
(Aug 1996)
ISSN: 0091-6749 [Print] United States |
PMID | 8757203
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androstadienes
- Anti-Inflammatory Agents
- Blood Proteins
- Eosinophil Granule Proteins
- Methacholine Chloride
- Fluticasone
- Ribonucleases
- Hydrocortisone
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Topics |
- Administration, Intranasal
- Adolescent
- Adult
- Androstadienes
(administration & dosage, pharmacology)
- Anti-Inflammatory Agents
(administration & dosage, pharmacology)
- Blood Proteins
(metabolism)
- Bronchial Hyperreactivity
(drug therapy, physiopathology)
- Bronchial Provocation Tests
- Double-Blind Method
- Drug Administration Schedule
- Eosinophil Granule Proteins
- Eosinophilia
(drug therapy)
- Female
- Fluticasone
- Humans
- Hydrocortisone
(urine)
- Male
- Methacholine Chloride
(administration & dosage)
- Middle Aged
- Nasal Lavage Fluid
(cytology)
- Pollen
- Rhinitis, Allergic, Seasonal
(drug therapy, pathology, physiopathology)
- Ribonucleases
- Seasons
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