Induction of intestinal epithelial proliferation by glucagon-like peptide 2.

Abstract	Injury, inflammation, or resection of the small intestine results in severe compromise of intestinal function. Nevertheless, therapeutic strategies for enhancing growth and repair of the intestinal mucosal epithelium are currently not available. We demonstrate that nude mice bearing subcutaneous proglucagon-producing tumors exhibit marked proliferation of the small intestinal epithelium. The factor responsible for inducing intestinal proliferation was identified as glucagon-like peptide 2 (GLP-2), a 33-aa peptide with no previously ascribed biological function. GLP-2 stimulated crypt cell proliferation and consistently induced a marked increase in bowel weight and villus growth of the jejunum and ileum that was evident within 4 days after initiation of GLP-2 administration. These observations define a novel biological role for GLP-2 as an intestinal-derived peptide stimulator of small bowel epithelial proliferation.
Authors	D J Drucker, P Erlich, S L Asa, P L Brubaker
Journal	Proceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 93 Issue 15 Pg. 7911-6 (Jul 23 1996) ISSN: 0027-8424 [Print] United States
PMID	8755576 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Glucagon-Like Peptide 2 Pancreatic Hormones Peptide Fragments Peptides Proliferating Cell Nuclear Antigen Protein Precursors glucagon-like peptide 1 (7-36)amide Proglucagon Glucagon-Like Peptides Glicentin Glucagon-Like Peptide 1 Glucagon
Topics	Animals Cell Division (drug effects) Glicentin Glucagon (biosynthesis, pharmacology) Glucagon-Like Peptide 1 Glucagon-Like Peptide 2 Glucagon-Like Peptides Glucagonoma (metabolism, pathology) Ileum (drug effects, pathology) Immunohistochemistry Intestinal Mucosa (drug effects, pathology) Jejunum (drug effects, pathology) Kinetics Mice Mice, Nude Organ Size (drug effects) Pancreatic Hormones (pharmacology) Pancreatic Neoplasms (metabolism, pathology) Peptide Fragments (pharmacology) Peptides (pharmacology) Proglucagon Proliferating Cell Nuclear Antigen (analysis) Protein Precursors (biosynthesis, pharmacology) Rats Transplantation, Heterologous

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!