[The consolidation and reproduction of a state of haloperidol-induced catalepsy].

Abstract

Catalepsy induced by a single intraperitoneal injection of haloperidol (2.5 mg/kg) was consolidated and without additional influences and retained within 2 week (being tested on the 2nd, 7th, and 14th days after injection). Enhancement of catalepsy retrieval was observed during testing of the same animals on the 14th day as compared with the 7th day. Maximal catalepsy expression was reached after 2 hours of testing procedure which points to the existence of the mechanism of autoenhancement of retrieval which is probably underlain by the automodulation of the long-lasting modulatory DA receptors. The retrieval of catalepsy is suggested to be induced by a situational conditioned stimulus, since on the 2nd, 7th and 14th days it may be reproduced without repeated haloperidol injection only in the testing box.

• Authors: A S Bazian, V M Getsova, N V Orlova
• Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova (Zh Vyssh Nerv Deiat Im I P Pavlova) 1996 May-Jun Vol. 46 Issue 3 Pg. 571-7 ISSN: 0044-4677 [Print] Russia (Federation)
• Vernacular Title: Konsolidatsiia i vosproizvedenie sostoianiia galoperidolovoĭ katalepsii.
• PMID: 8755063 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dopamine Antagonists
• Haloperidol

Topics

• Animals
• Catalepsy (chemically induced, physiopathology)
• Chi-Square Distribution
• Dopamine Antagonists
• Haloperidol
• Male
• Posture (physiology)
• Rats
• Rats, Wistar
• Statistics, Nonparametric
• Time Factors