[A clinico-biological study of the thrombocyte serotonin-transport complex in therapeutically resistant patients with endogenous depression undergoing combined treatment].

Abstract

The platelet parameters of the functional status of the serotonin-reuptake complex were studied in drug-resistant depressive patients given various regimens of complex therapy or selective serotonin re-uptake inhibitors (fluvoxamine and fluoxetine). The most persistent and marked clinical effect was seen in electroconvulsive therapy and it was due to the normalization of the serotonin-reuptake system.

• Authors: O S Brusov, G P Panteleeva, V V Bondar', V I Dikaia, M I Faktor, G P Zlobina, O A Pavlova, N V Abrosimov, R R Lideman
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 4 Pg. 29-32 ( 1996) ISSN: 0869-6047 [Print] Russia (Federation)
• Vernacular Title: Kliniko-biologicheskoe issledovanie serotonintransportnogo kompleksa trombotsitov u terapevticheski rezistentnykh bol'nykh éndogennoĭ depressieĭ pri kompleksnom lechenii.
• PMID: 8754076 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Serotonin

Topics

• Adult
• Biological Transport
• Bipolar Disorder (blood, therapy)
• Blood Platelets (metabolism)
• Combined Modality Therapy
• Depressive Disorder (blood, therapy)
• Drug Resistance
• Electroconvulsive Therapy
• Female
• Humans
• Male
• Schizophrenia (blood, therapy)
• Serotonin (blood)