[Two cases of lupus nephritis having a high titer of anti-(histone-DNA) complex antibody without IgG anti-dsDNA antibody].

Abstract

IgG antibody specific to double-stranded DNA (dsDNA) has been recognized as a predictive indicator of the renal involvement in systemic lupus erythematosus. However, we recently experienced two cases of overt lupus nephritis without IgG anti-dsDNA antibody. In both cases, high titers of antibody to the histone dimer (H2A-H2B)-dsDNA complex were detected. They responded well to the corticosteroid therapy, with a cytotoxic agent in one case, and the titers of anti-(histone-DNA) antibody was decreased along with the improvement of proteinuria. Based on the recent reports suggesting a pathogenic role of this antibody in lupus nephritis, we suggest that measurement of the anti-(histone-DNA) antibody is necessary in lupus nephritis patients, especially when IgG anti-dsDNA antibody is not detectable.

• Authors: N Mizushima, T Kubota, T Nanki, R Koike, H Kohsaka, N Miyasaka
• Journal: Rinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 44 Issue 6 Pg. 585-9 (Jun 1996) ISSN: 0047-1860 [Print] Japan
• PMID: 8752739 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antibodies, Antinuclear
• Antigen-Antibody Complex
• Histones
• Immunoglobulin G
• DNA

Topics

• Adult
• Antibodies, Antinuclear (analysis)
• Antigen-Antibody Complex (analysis)
• DNA (immunology)
• Female
• Histones (immunology)
• Humans
• Immunoglobulin G
• Lupus Nephritis (diagnosis)