Abstract |
Serum levels of cytokines and in vitro cytokine production by lymph node mononuclear cells (LNMC) were studied in four patients with angio- immunoblastic lymphadenopathy with dysproteinemia (AILD) or AILD-type T cell lymphoma. An increased level of serum interleukin-6 (IL-6) was detected on initial diagnosis in both of two patients examined. Spontaneous production of IL-6 by LNMC was detected in all four patients studied. Immunosuppressive therapy with cyclosporin A (CsA) was attempted in a 68-year-old man, who was refractory to intensive combination chemotherapy. The increased level of IL-6 in this patient decreased to normal within 3 weeks of CsA administration and the patient became symptom-free. One and a half months later, the IL-6 level gradually increased along with clinical exacerbation. We also measured serum levels of IL-1 alpha, IL-2, IL-4, IFN-alpha, gamma and TNF-alpha in parallel with IL-6, but these factors were only sporadically detected. IL-6 production by LNMC was stimulated by IL-2 but inhibited by CsA. These observations suggest that IL-6 is one of the important cytokines to be involved in the pathophysiology of AILD and CsA is a useful reagent for relieving symptoms.
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Authors | M Yamamura, M Honda, Y Yamada, T Itoyama, H Sohda, T Yubashi, S Momita, S Kamihira, Y Ohmoto, M Tomonaga |
Journal | Leukemia
(Leukemia)
Vol. 10
Issue 9
Pg. 1504-8
(Sep 1996)
ISSN: 0887-6924 [Print] England |
PMID | 8751470
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Interleukin-6
- Cyclosporine
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Topics |
- Aged
- Blood Protein Disorders
(blood, drug therapy, metabolism)
- Cyclosporine
(therapeutic use)
- Humans
- Immunoblastic Lymphadenopathy
(blood, drug therapy, metabolism)
- Immunosuppressive Agents
(therapeutic use)
- Interleukin-6
(biosynthesis, blood, physiology)
- Leukocytes, Mononuclear
(metabolism)
- Lymph Nodes
(cytology, metabolism)
- Lymphoma, T-Cell
(blood, drug therapy, metabolism)
- Male
- Middle Aged
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