Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats.

Abstract

We studied the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Under pentobarbital anesthesia, the celiac artery was clamped for 30 min and reperfused. Sixty minutes after the reperfusion, the total area of erosions and thiobarbituric acid-reactive substances in the stomach, as an index of lipid peroxidation, were measured and compared between control and cystathionine-treated groups. Intraperitoneal administration of cystathionine (1-20 mg/kg) 10 min before the ischemia significantly reduced both the total area of erosions and the level of thiobarbituric acid-reactive substances. When cystathionine (10 mg/kg) was administered orally, the significant reductions in the total area of erosions and level of thiobarbituric acid-reactive substances were also observed. There was a good correlation between the total area of erosions and the level of thiobarbituric acid-reactive substances. Cystathionine did not affect blood flow during ischemia-reperfusion. These results indicate that the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion may be due to the scavenging action against superoxide radicals in vivo.

• Authors: K Wada, Y Kamisaki, M Kitano, K Nakamoto, T Itoh
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 294 Issue 2-3 Pg. 377-82 (Dec 29 1995) ISSN: 0014-2999 [Print] Netherlands
• PMID: 8750697 (Publication Type: Journal Article)

Chemical References

• Free Radical Scavengers
• Cystathionine

Topics

• Animals
• Cystathionine (pharmacology)
• Free Radical Scavengers (pharmacology)
• Gastric Mucosa (blood supply, drug effects, metabolism)
• Ischemia (metabolism, pathology)
• Lipid Peroxidation
• Male
• Rats
• Rats, Wistar
• Regional Blood Flow (drug effects)
• Reperfusion Injury (pathology, prevention & control)