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A new approach to the control of central deafferentation pain--spinal intrathecal baclofen.

Abstract
We investigated the short-term effects of an intrathecal bolus injection of baclofen on central pain due to stroke or spinal cord injury. Pain relief was obtained in 64% of the patients. The effects developed 1-2 hours after the injection and continued for 10-24 hours. Both spinal segmental and supraspinal mechanisms may be involved in the production of baclofen-analgesia.
AuthorsT Taira, H Kawamura, T Tanikawa, H Kawabatake, H Iseki, A Ueda, K Takakura
JournalActa neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 64 Pg. 136-8 ( 1995) ISSN: 0065-1419 [Print] Austria
PMID8748602 (Publication Type: Journal Article)
Chemical References
  • Muscle Relaxants, Central
  • Baclofen
Topics
  • Afferent Pathways (drug effects)
  • Aged
  • Baclofen (administration & dosage, adverse effects)
  • Cerebrovascular Disorders (complications)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Humans
  • Injections, Spinal
  • Male
  • Middle Aged
  • Muscle Relaxants, Central (administration & dosage, adverse effects)
  • Pain (drug therapy)
  • Spinal Cord Injuries (complications)

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