Effects of selenium and vitamin E deficiencies on reproduction, growth, blood components, and tissue lesions in sheep fed purified diets.

Abstract

Three 2 X 2 factorial experiments were conducted with sheep fed purified diets to determine the effects of selenium and vitamin E on the incidence of white muscle disease (WMD) and blood components. All lambs reaching 6 weeks of age in the group receiving no vitamin E or selenium developed WMD lesions, whereas only a few lambs in either the +E - Se or -E + Se treatment groups developed these lesions. Plasma activities of creatine phosphokinase, lactic dehydrogenase and glutamic oxaloacetic transaminase were significantly elevated in lambs receiving no vitamin E or selenium, whereas these enzyme activities in those receiving only selenium were non-significantly elevated. The enzyme activities in plasma of those on the +E - Se or +E + Se treatments were maintained at low levels, suggesting vitamin E alone is more effective in preventing WMD than selenium alone. The metabolic interactions of these essentials are discussed.

• Authors: P D Whanger, P H Weswig, J A Schmitz, J E Oldfield
• Journal: The Journal of nutrition (J Nutr) Vol. 107 Issue 7 Pg. 1288-97 (Jul 1977) ISSN: 0022-3166 [Print] United States
• PMID: 874572 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Vitamin E
• L-Lactate Dehydrogenase
• Aspartate Aminotransferases
• Creatine Kinase
• Selenium

Topics

• Age Factors
• Animals
• Aspartate Aminotransferases (blood)
• Birth Weight
• Creatine Kinase (blood)
• Female
• Fetal Death
• L-Lactate Dehydrogenase (blood)
• Litter Size
• Muscular Dystrophy, Animal (etiology)
• Pregnancy
• Pregnancy Complications (metabolism)
• Reproduction
• Selenium (deficiency, metabolism)
• Sheep (metabolism)
• Vitamin E (blood)
• Vitamin E Deficiency (complications, physiopathology)
• White Muscle Disease (etiology)