[Muscular involvement in HIV infection].

Abstract

Skeletal muscle involvement may occur at all stages of HIV-infection and represents the first manifestation of the disease in some patients. We usually classify muscle involvement in HIV-infected patients in one of the following categories: (1) HIV-associated myopathy, a myopathy that meets the criteria for polymyositis in a majority of patients, and those for acquired nemaline myopathy in some; (2) zidovudine myopathy, a reversible mitochondrial myopathy; (3) the HIV-wasting syndrome and other AIDS-associated cachexias; (4) opportunistic infections and tumoral infiltrations of the skeletal muscle; (5) vasculitic processes and iron pigment deposits; (6) HIV-associated myasthenia gravis and (7) rhabdomyolysis. Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correct classification of a myopathy as HIV polymyositis or zidovudine myopathy.

• Authors: R Gherardi, P Chariot, F J Authier
• Journal: Revue neurologique (Rev Neurol (Paris)) Vol. 151 Issue 11 Pg. 603-7 (Nov 1995) ISSN: 0035-3787 [Print] France
• Vernacular Title: Les atteintes musculaires au cours de l'infection par le VIH.
• PMID: 8745623 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Reverse Transcriptase Inhibitors
• Zidovudine

Topics

• HIV Infections (complications, drug therapy)
• Humans
• Muscular Diseases (chemically induced, etiology)
• Reverse Transcriptase Inhibitors (adverse effects)
• Zidovudine (adverse effects)